The Formula

What it is. Nicotinamide Riboside is a form of vitamin B3. The body converts it to NAD+, a coenzyme present in every living cell and involved in energy metabolism, DNA repair, and a wide range of other biological processes. NAD+ is known to decline with age.

Why it is in TREMODI. NAD+ has become one of the most studied molecules in longevity science. Research has examined its role in mitochondrial function, in the sirtuin pathway, and in the cellular repair systems involving PARP enzymes. We chose 300mg because it sits within the dose range used in published human trials. Not a token amount. A considered one.

Why NR, not NMN: you will more often see NMN on a longevity label, and there is genuine science behind it. We chose NR for two plain reasons. NR is cleared for sale in the UK as an authorised novel food, its safety formally assessed. NMN has not cleared that bar here, and its UK status is unsettled. And NR has the longer record of completed human trials at the 300mg dose we use, while NMN's strongest evidence is still arriving.

The research. Dellinger et al · npj Aging 2017

What it is. Trimethylglycine, also known as betaine, is a compound found in beetroot, spinach, and certain whole grains. In the body it donates methyl groups, a process involved in gene expression, DNA repair, and the metabolism of homocysteine.

Why it is in TREMODI. The conversion of NR to NAD+ in the body uses methyl groups. Researchers have explored this, which is why methyl donors like TMG are often discussed alongside NR in the longevity literature. The dose in TREMODI is lower than the doses studied in standalone homocysteine trials, which typically use grams. We use 300mg because it pairs sensibly with the NR alongside it, not as a treatment for any condition on its own.

The research. McRae · J Chiropr Med 2013

What it is. Rhodiola Rosea is a flowering plant from the high altitudes of Europe and Asia, used in traditional herbal practice for centuries. The extract used in TREMODI is Rhodiolife®, a standardised, studied form with consistent levels of the active compounds rosavins and salidroside.

Why it is in TREMODI. Rhodiola is one of the most researched botanicals in the broad category of fatigue and stress, with a long tradition of use in northern Europe and central Asia. We chose Rhodiolife specifically because standardisation matters. A Rhodiola extract that is not characterised for active compounds is a different ingredient every time you buy it. Rhodiolife is the same profile in every capsule.

The research. Ishaque et al · BMC CAM 2012

What it is. Quercetin is a flavonoid found naturally in onions, apples, capers, and green tea, one of the most widely studied plant compounds in nutritional research.

Why it is in TREMODI. Flavonoids are a major area of interest in research on inflammation, oxidative stress, and metabolic biology. Quercetin in particular has appeared in longevity-focused research alongside other compounds, including in the senescent cell literature. We chose it because it is a well-studied compound at a sensible dose.

The research. Mohammadi-Sartang et al · Eur J Clin Nutr 2017

What it is. L-Theanine is an amino acid found almost exclusively in tea leaves. TREMODI uses a synthetic L-Theanine, chemically identical to the form found in tea, produced through an enzymatic process to deliver the pure L-isomer. We chose a synthetic source over a green-tea extract for a simple reason: consistency. A characterised L-Theanine is the same molecule in every capsule.

Why it is in TREMODI. Demanding lives create chronic cognitive load. L-Theanine has been examined in research on stress markers, cortisol response, and subjective measures of calm focus. We chose it because the research interests us, the dose sits within trial-studied levels, and most products in this category ignore the nervous system entirely.

The research. Hidese et al · Nutrients 2019

What it is. Resveratrol is a polyphenol produced by certain plants under stress, found in red grape skin, blueberries, and Japanese knotweed. Trans-Resveratrol is the biologically active form. TREMODI uses 98% pure Trans-Resveratrol, not a standardised extract diluted with inert material.

Why it is in TREMODI. Resveratrol has been the subject of extensive longevity research, with particular focus on the sirtuin pathway and on mitochondrial biology. The evidence base is wide, and it is evolving. We chose to include it because we use a pure form at a research-relevant dose, and because the conversation continues to produce new work. You will see resveratrol sold at 500mg, 1000mg, sometimes more. More looks like better. But resveratrol is poorly absorbed on its own, and most of a large dose is broken down before it ever reaches the bloodstream. We use 100mg of a 98% pure form, alongside the BioPerine in the formula that research has examined for its effect on how much resveratrol the body takes up. The aim is a dose your body can use, not a number that looks impressive on a label.

The research. Zhou et al · Diab Metab Syndr 2021 · Pollack et al · J Gerontol A 2017

What it is. Coenzyme Q10 is a fat-soluble compound found in every cell of the body, concentrated in the mitochondria. It plays a role in the electron transport chain, the cellular process that produces ATP. CoQ10 levels are known to decline with age.

Why it is in TREMODI. CoQ10 is one of the most extensively studied compounds in cellular biology. Research has examined it across cardiovascular, neurological, and metabolic outcomes, with the Cochrane Collaboration revisiting the evidence base more than once. A note on this ingredient: TREMODI uses Ubiquinone, the oxidised form of CoQ10, rather than the more expensive Ubiquinol. The body converts Ubiquinone to Ubiquinol naturally during absorption. TREMODI is designed to support that conversion: taken with the fat-containing meal we recommend, alongside the BioPerine in the formula. We chose Ubiquinone to keep TREMODI as accessible as we could without compromising on the rest of the formula.

The research. Madmani et al · Cochrane 2014

What it is. Pyrroloquinoline quinone is a quinone-class compound studied for its relationship with mitochondrial biology. It is present at low levels in some foods including fermented soybeans, parsley, and certain teas.

Why it is in TREMODI. Among the compounds in mitochondrial research, PQQ has drawn attention for its association with mitochondrial biogenesis, the process by which new mitochondria form within cells. 10mg is the standard formulating dose used in capsule-form supplements, and it pairs naturally with the other mitochondrial-relevant compounds in TREMODI.

The research. Itoh et al · Adv Exp Med Biol 2016

What it is. BioPerine® is a patented black pepper extract standardised to 95% piperine. Pharmacokinetic research has examined piperine's effect on the enzymes and transporters involved in the digestive breakdown of other compounds.

Why it is in TREMODI. Several ingredients in TREMODI are subject to rapid breakdown in the digestive tract. BioPerine is here to address that. 5mg is the standard dose Sabinsa, the patent holder, formulates BioPerine for in capsule supplements. Taken with a fat-containing meal as TREMODI is designed to be, it does the job it is here to do.

The research. Shoba et al · Planta Medica 1998

The conversion of NR to NAD+ in the body uses methyl groups. Researchers have explored this, and methyl donors like TMG often appear in NR-related conversations. TREMODI includes both because the literature treats them as sensible companions.

All three appear in mitochondrial research, examined in different parts of the same biology. NR in the context of NAD+ availability. CoQ10 in the electron transport chain. PQQ in mitochondrial biogenesis. Each is its own research conversation, and we chose all three deliberately.

Trans-Resveratrol is fat-soluble. Pharmacokinetic research has examined how poorly it is absorbed on its own, and what changes when taken with absorption-enhancing compounds. BioPerine appears in many of these conversations.

Both work on the nervous system rather than the cellular machinery the rest of the formula targets. Rhodiola is researched in the context of fatigue and stress resilience. L-Theanine is researched in the context of stress markers, cortisol response, and calm focus. TREMODI pairs them deliberately, not as an afterthought.

TREMODI is made by Lifesource Supplements Ltd, a UK facility independently audited by Eurofins Assurance UK against Good Manufacturing Practice and HACCP food safety standards.

The Certificate of Analysis for batch one will be published on this page on launch day, with each later batch after it. No proprietary blends. Nothing to hide behind.

It would be easy to make bigger promises. Cures, reversals, guarantees, the language this category reaches for by default. I didn't reach for it. TREMODI is a food supplement. It does not treat, prevent, or cure any condition. Where a mechanism is described or a study cited, that is what researchers have examined, not what TREMODI will do for you. That is not a hedge. It is the whole point.